Indian Institute of Technology Delhi
Ruthenium(II)-Catalyzed C-H Functionalization and Photo-Redox Catalysis
Dr. Keshav Raghuvanshi
Department of Chemistry at University of Iowa, Iowa City, USA.
Date: August 10th 2017 (Thursday)
Time: 4 PM
Venue: Committee Room, Chemistry Department, 6th Floor
Regioselective C–H bond transformations are potentially the most efficient method for the synthesis of organic molecules. However, the presence of many C–H bonds in organic molecules and the high activation barrier for these reactions make these transformations difficult. On the tide of progress towards sustainable chemistry,(1) the transition metal catalysis of unfunctionalized hetero-arenes through C-H activation is currently garnering tremendous attention because laborious arene prefunctionalization like that required for the Mizoroki–Heck reaction.(2)
These protocols will provide an appealing alternative to existing approaches to construct useful C-H functionalized arene and heteroarene derivatives, which may be used as key intermediates in the synthesis of drug candidates. The net redox-neutral method to generate carbon radicals and couple them with Michael acceptors by visible-light- promoted functionalization of arenes using the photo-catalyst Ir[dF(CF3)ppy]2(dtbbpy)PF6 and inter-alia others.
To meet the demand of green chemistry, a C-H functionalization should: 1) minimize the cost and waste associated with stoichiometric additives, and 2) avoid harsh reaction conditions which may be incompatible with sensitive functionalities. The development of innovative directing groups, which enable novel transformations to deliver valuable structures under mild and simple reaction conditions, are highly desirable.
- P. Anastas, N. Eghbali, Chem. Soc. Rev. 2010, 39, 301-312.
- The Mizoroki–Heck Reaction (Ed. : M. Oes- treich), Wiley, Chichester, 2009.
All are cordially invited to attend.